Injectables · Neurotoxins
Xeomin (incobotulinumtoxinA) is an FDA-approved neuromodulator that smooths frown lines and dynamic wrinkles — formulated without complexing or accessory proteins. At Aurevia in Irvine, our expert injectors use this "naked" botulinum toxin for patients who want a clean, precise treatment with dosing units comparable to Botox.
A consultation confirms candidacy and unit dosing. Xeomin units are similar to Botox — not interchangeable with Dysport's different unit ratio. Only an experienced injector should calculate your dose.
Xeomin is sometimes called a "naked" or purified neurotoxin because it contains only incobotulinumtoxinA, human albumin, and sucrose — with no complexing or accessory proteins. This streamlined formulation may reduce the risk of antibody formation in patients who have stopped responding to other brands.
| Feature | Botox | Dysport | Xeomin |
|---|---|---|---|
| Active ingredient | OnabotulinumtoxinA | AbobotulinumtoxinA | IncobotulinumtoxinA |
| Complexing / accessory proteins | Yes — present in formulation | Yes — present in formulation | No — none present |
| Other excipients | Human albumin, sodium chloride | Human albumin, lactose | Human albumin, sucrose |
| Unit ratio vs. Botox | 1 : 1 (reference) | ~2.5–3 units per Botox unit | 1 : 1 (similar dosing) |
| Antibody formation risk | Possible with repeated use | Possible with repeated use | May be reduced — no accessory proteins |
| FDA cosmetic approval | 2002 (glabellar) | 2009 (glabellar) | 2011 (glabellar) |
A quick, in-office procedure. Most appointments take 15–30 minutes. Your Aurevia injector reviews your plan, cleans each site, and administers precise units with an ultra-fine needle. Xeomin dosing follows a Botox-comparable unit scale — your provider maps injection points based on your facial anatomy, not a template.
Minimal downtime, simple aftercare. Stay upright for 4 hours after treatment; avoid vigorous exercise for 24 hours; skip rubbing or massaging the treated area; hold off on alcohol for 24 hours. Most patients return to normal activities immediately — making Xeomin an easy fit for a busy Irvine schedule.
Gradual softening, lasting smoothness. Most patients notice improvement within 3–7 days, with full effect typically visible by two weeks. Results last approximately 3–4 months on average. Regular maintenance helps preserve a refreshed appearance and may train overactive muscles to crease less over time.
Priced per unit or by area. Irvine Xeomin sessions typically range from $600 – $1,200, depending on areas treated, units required, and injector expertise. Because Xeomin units are comparable to Botox — unlike Dysport — your quote reflects a straightforward per-unit calculation. We provide transparent pricing at consultation.
Xeomin is not necessarily "better" than Botox or Dysport — it is different. Our Irvine injectors often recommend it when formulation purity or treatment history points toward this specific profile.
Patients who notice shorter duration or weaker results after years of Botox may have developed antibodies to accessory proteins — Xeomin's protein-free formula can be a logical next step.
Those who prefer fewer excipients in their injectable may choose Xeomin for its three-component formula: incobotulinumtoxinA, human albumin, and sucrose.
Xeomin units are dosed similarly to Botox (1:1), making transitions simpler than switching to Dysport's different unit ratio.
Some patients begin with Xeomin when they want a purified entry point into neuromodulator treatment — though Botox and Dysport remain excellent first-line options.
FDA-approved for moderate to severe glabellar lines; commonly used off-label for forehead and crow's feet with experienced injectors.
Xeomin is also FDA-approved for cervical dystonia and blepharospasm — our providers can discuss whether a therapeutic indication applies.
The injection technique is identical to other neuromodulators — ultra-fine needles, anatomy-based mapping, and Botox-comparable units. What differs is what's in the vial: a purified toxin without complexing proteins.
We document prior neurotoxin brands, unit counts, duration of results, and any signs of resistance — critical when selecting Xeomin.
Expression lines are assessed at rest and in motion. Injection points are marked based on muscle anatomy, not a generic template.
Precise Xeomin units are placed with an ultra-fine needle. Most sessions take 15–30 minutes; discomfort is typically minimal.
We schedule a two-week check if needed and advise when to return for maintenance — usually every 3–4 months.
FDA-approved indication — vertical frown lines between the eyebrows that create a tired or stern expression.
Horizontal creases from brow elevation — treated with careful dosing to preserve natural brow position.
Periorbital lines at the outer eye — small doses preserve natural smiling while softening etched lines.
Nasal scrunch lines — conservative placement avoids affecting adjacent muscles.
Subtle upper lip relaxation or softening of vertical lip lines for a fresher mouth area.
Vertical neck cords from platysma muscle activity — a nonsurgical approach to a smoother neckline when candidacy is appropriate.
Xeomin is a prescription injectable containing incobotulinumtoxinA — a purified form of botulinum toxin type A. The FDA approved Xeomin for therapeutic use in 2010 and for cosmetic treatment of glabellar (frown) lines in 2011.
Unlike Botox and Dysport, Xeomin is manufactured without complexing or accessory proteins. Its formulation contains only three components: incobotulinumtoxinA, human albumin, and sucrose. This "naked" structure means there are fewer foreign proteins for the immune system to recognize — which may reduce the likelihood of antibody formation in patients who have lost responsiveness to other neurotoxins.
When injected into targeted facial muscles, Xeomin temporarily blocks nerve signals that trigger contraction. Muscles relax, skin above them smooths, and dynamic wrinkles soften. Unit dosing is similar to Botox, making it a straightforward alternative for patients seeking a purified option at Aurevia in Irvine.
Choosing the right neurotoxin is about more than brand name — it's about matching formulation to your history, anatomy, and goals. At Aurevia, our Irvine injectors have extensive experience with Xeomin and understand when its purified profile offers the best path forward — especially for patients exploring alternatives after diminished results with other products.Aurevia Skincare · Irvine, CA
Xeomin contains incobotulinumtoxinA without complexing or accessory proteins — only human albumin and sucrose accompany the active ingredient. Botox and Dysport include additional proteins in their formulations. Xeomin units are dosed similarly to Botox (1:1), whereas Dysport requires roughly 2.5–3 units for every one Botox unit. This purified profile may reduce antibody formation in patients who have stopped responding to other brands.
The FDA approved Xeomin for therapeutic indications — including cervical dystonia and blepharospasm — in 2010. Cosmetic approval for moderate to severe glabellar (frown) lines followed in 2011. It has since become a trusted option for patients seeking a protein-free neuromodulator.
Most Irvine Xeomin patients notice softening within 3–7 days, with full effect typically visible by two weeks. Onset is comparable to Botox. Individual timing varies with metabolism, muscle strength, and treatment area.
Results typically last approximately 3–4 months, similar to Botox and Dysport. Duration depends on dose, treatment area, and individual metabolism. Maintenance visits every few months help preserve smoothness over time.
Common side effects include temporary redness, swelling, or bruising at injection sites, headache, and — rarely — eyelid or brow drooping if product migrates. Because Xeomin contains human albumin, disclose any albumin allergy before treatment. Patients with neuromuscular disorders such as myasthenia gravis should discuss risks with their provider. We review your full medical history during consultation.
Yes. Because Xeomin units are comparable to Botox (unlike Dysport), many patients transition with straightforward unit recalculation. We recommend waiting until prior neurotoxin has largely worn off before switching, so we can assess your baseline muscle activity and adjust dose accurately.
Unlike some neurotoxins, Xeomin can be stored at room temperature before reconstitution — a practical advantage for clinic workflow. Once reconstituted, it must be used within the manufacturer-specified timeframe. This does not affect your treatment experience; our Aurevia team follows strict handling protocols for every product.
Aurevia is the premier Irvine skincare clinic for aesthetic and beauty treatments. Discover whether Xeomin's purified formulation is right for you with a complimentary consultation from our highly trained injectors.